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“The book brings together an outstanding list of researchers to update our current knowledge of the anatomy, behavioral functioning, and disease states of the frontal lobes….This continues to be an excellent resource on the frontal lobes. The new chapters are relevant to clinical practice and research. The book also has a much more integrated approach across the book, with neuroanatomy, neurochemistry, neuropsychology, neurogenetics, and neuroimaging. This edition is sufficiently updated on current issues in the field [and] is a worthwhile replacement of the previous edition. *****!”

—Doody's Review Service


“A comprehensive, well-organized, and authoritative book. Prior editions have been on the required reading lists for trainees and practitioners in behavioral neurology, neuropsychiatry, neuropsychology, and cognitive neuroscience. In the third edition, the editors have reorganized the material and added a variety of new topics, including frontal systems dysfunction in a number of psychiatric disorders and expanded coverage of treatment. Miller and Cummings have mentored a generation of clinicians and scientists toward a nuanced understanding of frontal systems function and dysfunction. This book brings their passion for the subject to a new level of sophisticated scholarship.”

—Brad Dickerson, MD, Tom Rickles Chair in Progressive Aphasia Research and Director, Frontotemporal Disorders Unit, Massachusetts General Hospital; Associate Professor of Neurology, Harvard Medical School


“Provides comprehensive coverage of frontal lobe neuroanatomy, neurochemistry, and neuropsychology, with an emphasis on the clinical presentation of and state-of-the-art treatments for frontal dysfunction across neurological and psychiatric syndromes. The editors—major figures in behavioral neurology and intellectual descendants of D. Frank Benson—have assembled an incredibly strong cast of contributors to bring this work to fruition. The enormous scope is complemented by critical depth in each chapter; the density of novel material shows how much has been learned over the last decade.”

—Robert M. Bilder, PhD, ABPP-CN, Michael E. Tennenbaum Family Professor of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles


“It wasn’t long ago that scientists and clinicians considered the frontal lobes an enigma and could teach only vaguely about their functions. The fresh and contemporary third edition of this acclaimed work provides readers with succinct critical analyses of newly discovered mechanisms and functions of the frontal lobes. This book can serve as a core text for advanced students in cognitive and clinical neuroscience who need to acquire foundational principles in frontal lobe investigation and patient management. With up-to-date coverage of imaging; neuropsychiatric disorders; genetics; treatment approaches; and networks underlying salience, social behavior, and apathy, it will also enable seasoned scientists and clinicians to stay current with 21st-century frontal lobe neuroscience breakthroughs.”

—Paul J. Eslinger, PhD, Professor of Neurology, Neural and Behavioral Sciences, and Radiology, Penn State Hershey Medical Center and College of Medicine

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Table of Contents

I. Neuroanatomy and Neurochemistry

1. The Human Frontal Lobes: An Introduction, Bruce L. Miller and Jeffrey L. Cummings

2. The Mesocortical Dopaminergic System, Billy T. Chen and Antonello Bonci

3. The Dorsolateral and Cingulate Cortex , James R. Bateman and Daniel I. Kaufer

4. The Orbitofrontal Cortex and the Insula, Eun-Joo Kim, Jennifer Ogar, and Maria Luisa Gorno-Tempini

5. Structural and Functional Asymmetries of the Human Frontal Lobes, Daniel H. Geschwind and Marco Iacoboni

6. Gross Morphology and Architectonics, Helmut Heinsen and Lea Tenenholz Grinberg

II. Assessment: Neuropsychology and Behavior

7. The Frontal Lobes and Executive Control, Adam Gazzaley, Taraz G. Lee, and Mark D’Esposito

8. Bedside Frontal Lobe Testing, Adam M. Staffaroni, Melanie L. Stephens, and Joel H. Kramer

9. The Prefrontal Cortex and Human Memory, Nick Diamond and Brian Levine

10. Language and Frontal Cortex, Marlís González-Fernández and Argye E. Hillis

11. Self-Awareness and Frontal Lobe Networks, Virginia E. Sturm, Alice Y. Hua, and Howard J. Rosen

12. Decision-Making Capacity and Frontal Lobe Dysfunction, Sarah M. Hooper and Winston Chiong

13. Socioemotional Functioning and Frontal Lobe Injury, Katherine P. Rankin, Kelly Gola, and Tracy L. Jerard

14. Salience Networks: Magnetic Resonance Imaging Interrogation of Self-Concepts in Dementia, Winston Chiong

III. Neurological Diseases

Section A: FTD and Related Disorders

15. Clinical Aspects of Frontotemporal Dementia, David C. Perry and Bruce L. Miller

16. Progressive Supranuclear Palsy, Corticobasal Degeneration, and the Frontal Cortex, Anne-Catherine Vijverman, Maria Carmela Tartaglia, and Anthony E. Lang

17. Neuropathology of Frontotemporal Dementias, Nigel J. Cairns, David J. Irwin, Vivianna M. Van Deerlin, Virginia M.-Y. Lee, and John Q. Trojanowski

18. Frontotemporal Dementia Neurogenetics, Leonel T. Takada

Section B: Other Disorders

19. Normal Aging of the Frontal Lobes, Brianne Bettcher

20 . Vascular Cognitive Impairment: Executive Dysfunction in the Era of the Human Brain Connectome, Helena C. Chui and Liliana Ramirez Gomez

21. White Matter Diseases of the Frontal Lobes, Christopher M. Filley

22 . Parkinson’s Disease, Parkinson’s Disease with Dementia, and Dementia with Lewy Bodies, Jee Bang, Sharon J. Sha, and Katherine L. Possin

23. Traumatic Brain Injury, Judith Aharon-Peretz

IV. Neuropsychiatric Disorders

24. Prefrontal Cortical Dysfunction in Schizophrenia: Clinical Implications and Novel Treatment Development, Daniel Fulford, Joshua D. Woolley, and Sophia Vinogradov

25. Mania and the Frontal Lobes, Mary G. De May and Bruce L. Miller

26. Obsessive–Compulsive Disorder, Edwin H. Rodriguez and Carol A. Mathews

27 . Depression and the Frontal Lobes, Ira Lesser, Julia Chung, and Weiguo Zhu

28. Apathy, Georges Naasan

29 . Frontal Lobe Seizures, Frontal Cortex, and Dissociative States, Anli Liu and Orrin Devinsky

30 . The Role of the Frontal Lobes in Antisocial and Aggressive Behavior: Review of the Research and Legal Implications, Annette L. Ermshar and Kyle Brauer Boone

V . Treatment

31. Neurosurgical Treatments for Psychiatric Disorders, Simon Ducharme, Darin D. Dougherty, and Bruce H. Price

32 . Clinical Trials in Frontotemporal Lobar Degeneration, Gabriel C. Léger, Sarah J. Banks, and Jeffrey L. Cummings

Index

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About the Editors

Bruce L. Miller, MD, is the A. W. and Mary Margaret Clausen Distinguished Professor of Neurology at the University of California, San Francisco (UCSF), and Director of the UCSF Memory and Aging Center. Dr. Miller is a behavioral neurologist focused on dementia, with special interests in brain-behavior relationships as well as the genetic and molecular underpinnings of disease. He currently conducts research on frontotemporal dementia, oversees a program on healthy aging, and helps lead two privately funded research consortia. Dr. Miller is a recipient of the Potamkin Prize from the American Academy of Neurology, the Raymond D. Adams Lectureship from the American Neurological Association, the J. Elliot Royer Award from the San Francisco Neurological Society, the UCSF Annual Faculty Research Lectureship in Clinical Science, and the Gene D. Cohen Research Award in Creativity and Aging from the National Center for Creative Aging, among many other honors. With more than 700 scientific publications, Dr. Miller has served since 1984 as Scientific Director of the John Douglas French Alzheimer’s Foundation. He is a member of the National Academy of Medicine.

• Author's website

Jeffrey L. Cummings, MD, ScD, is Director of the Cleveland Clinic Lou Ruvo Center for Brain Health in Las Vegas, Nevada, and Cleveland, Ohio. He is the Camille and Larry Ruvo Chair for Brain Health at the Cleveland Clinic Neurological Institute and Professor of Medicine at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. A leading authority on Alzheimer's disease, Dr. Cummings is interested in clinical trials, developing new therapies for brain diseases, and the interface of neuroscience and society. He is a recipient of the Edward Henderson Award from the American Geriatrics Society, the Research Award from the John Douglas French Alzheimer’s Foundation, the Ronald and Nancy Reagan Research Institute Award from the Alzheimer’s Association, the Distinguished Scientist Award from the American Association for Geriatric Psychiatry, and the Lifetime Achievement Award from the Society for Behavioral and Cognitive Neurology, among many other honors. Dr. Cummings has more than 700 scientific publications and is a past president of the Behavioral Neurology Society and the American Neuropsychiatric Association.

• Author's website

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Contributors

Judith Aharon-Peretz, MD, Cognitive Neurology Unit, Rambam Health Care Campus, Haifa, Israel

Jee Bang, MD, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland

Sarah J. Banks, PhD, Lou Ruvo Center for Brain Health, Cleveland Clinic, Las Vegas, Nevada

James R. Bateman, MD, Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado

Brianne M. Bettcher, PhD, Departments of Neurosurgery and Neurology, University of Colorado School of Medicine, Aurora, Colorado

Antonello Bonci, MD, National Institute on Drug Abuse, Bethesda, Maryland; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland

Kyle Brauer Boone, PhD, California School of Forensic Studies, Alliant International University, and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California

Nigel J. Cairns, PhD, Department of Neurology, Washington University School of Medicine, St. Louis, Missouri

Billy T. Chen, PhD, Corporate Development, Ionis Pharmaceuticals, Inc., Carlsbad, California

Winston Chiong, MD, PhD, Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California

Helena C. Chui, MD, Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California

Julia Chung, MD, Department of Psychiatry and Biobehavioral Sciences, Harbor–UCLA Medical Center, Torrance, California

Jeffrey L. Cummings, MD, Lou Ruvo Center for Brain Health, Cleveland Clinic, Las Vegas, Nevada

Mary G. De May, MD, Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California

Mark D’Esposito, MD, Department of Psychology, University of California, Berkeley, Berkeley, California

Orrin Devinsky, MD, Department of Neurology, New York University School of Medicine, New York, New York

Nicholas B. Diamond, MA, Department of Psychology, University of Toronto, and Rotman Research Institute, Baycrest, Toronto, Ontario, Canada

Darin D. Dougherty, MD, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Belmont, Massachusetts

Simon Ducharme, MD, Department of Psychiatry, McGill University Health Centre, McGill University, Montréal, Québec, Canada

Annette L. Ermshar, PhD, Department of Forensic Psychology, California School of Forensic Studies, Alliant International University, Alhambra, CaliforniaChristopher M. Filley, MD, Departments of Neurology and Psychiatry, University of Colorado School of Medicine, Aurora, Colorado

Daniel Fulford, PhD, Department of Psychological and Brain Sciences, Boston University, Boston, Massachusetts

Adam Gazzaley, MD, Department of Neurology, University of California, San Francisco, San Francisco, California

Daniel H. Geschwind, MD, PhD, Department of Neurology, University of California, Los Angeles, Los Angeles, California

Kelly Gola, PhD, Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California

Marlís Gonzalez-Fernandez, MD, PhD, Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, Maryland

Maria Luisa Gorno-Tempini, MD, Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California

Lea Tenenholz Grinberg, MD, Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California

Helmut Heinsen, MD, Department of Psychiatry, University of Würzburg, Würzburg, Germany

Argye E. Hillis, MD, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland

Sarah M. Hooper, JD, University of California Hastings College of the Law, San Francisco, California

Alice Y. Hua, BA, Department of Psychology, University of California, Berkeley, Berkeley, California

Marco Iacoboni, MD, PhD, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California

David J. Irwin, MD, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

Tracy L. Jerard, PhD, Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California

Daniel I. Kaufer, MD, Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, North Carolina

Eun-Joo Kim, MD, Department of Neurology, Pusan National University Hospital, Pusan, South Korea

Joel H. Kramer, PsyD, Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California

Anthony E. Lang, MD, Toronto Western Hospital and Division of Neurology, University of Toronto, Toronto, Ontario, Canada

Taraz G. Lee, PhD, Department of Psychology, University of Michigan, Ann Arbor, Michigan

Virginia M.-Y. Lee, PhD, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

Gabriel C. Léger, MD, Lou Ruvo Center for Brain Health, Cleveland Clinic, Las Vegas, Nevada

Ira Lesser, MD, Department of Psychiatry and Biobehavioral Sciences, Harbor– UCLA Medical Center, Torrance, California

Brian Levine, PhD, Department of Psychology, University of Toronto, and Rotman Research Institute, Baycrest, Toronto, Ontario, Canada

Anli Liu, MD, Department of Neurology, New York University School of Medicine, New York, New York

Carol A. Mathews, MD, Department of Psychiatry, University of Florida College of Medicine, Gainesville, Florida

Bruce L. Miller, MD, Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California

Georges Naasan, MD, Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California

Jennifer Ogar, MD, Center for Aphasia and Related Disorders, Veterans Affairs Northern Health Care System, Martinez, California

David C. Perry, MD, Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California

Katherine L. Possin, PhD, Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California

Bruce H. Price, MD, Department of Neurology, McLean Hospital, Harvard Medical School, Belmont, Massachusetts

Liliana Ramirez-Gomez, MD, Department of Neurology, University of California, San Francisco, San Francisco, California

Katherine P. Rankin, PhD, Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California

Edwin H. Rodriguez, PhD, Biophysics Graduate Program, School of Medicine, University of California, San Francisco, San Francisco, California

Howard J. Rosen, MD, Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California

Sharon J. Sha, MD, Department of Neurology and Neuropsychological Sciences, Stanford University School of Medicine, Stanford, California

Adam M. Staffaroni, MS, Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California

Melanie L. Stephens, PhD, Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California

Virginia E. Sturm, PhD, Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California

Leonel Tadao Takada, MD, Department of Neurology, University of São Paulo Medical School, São Paulo, Brazil

Maria Carmela Tartaglia, MD, Tanz Center for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada

John Q. Trojanowski, MD, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

Vivianna M. Van Deerlin, MD, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

Anne-Catherine Vijverman, MD, Toronto Western Hospital and Division of Neurology, University of Toronto, Toronto, Ontario, Canada

Sophia Vinogradov, MD, Department of Psychiatry, University of Minnesota Medical School, Minneapolis, Minnesota

Joshua D. Woolley, MD, Department of Psychiatry, University of California, San Francisco, and San Francisco Veterans Affairs Medical Center, San Francisco, California

Weiguo Zhu, MD, PhD, Department of Psychiatry and Biobehavioral Sciences, Harbor–UCLA Medical Center, Torrance, California

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Audience

Clinicians, students, and researchers in neuropsychology and neuroscience, psychiatry, neurology, clinical psychology, and gerontology.

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Course Use

May serve as a supplemental text in graduate-level courses.

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Previous editions published by Guilford:

Second Edition, © 2007
ISBN: 9781593853297

First Edition, © 1999
ISBN: 9781572303904

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New to this edition:

• Reflects a decade of important research advances in such areas as functional connectivity mapping of frontal and frontal–subcortical circuits.
• Incorporates significant new information on frontotemporal dementia and other neurological disorders.
• Expanded section on neuropsychiatric disorders, with new chapters on apathy, dissociative states, and antisocial behavior.
• Chapters on salience networks, normal brain aging, white matter diseases, and clinical trials.
• Increased attention to brain processes involved in moral reasoning, empathy, decision making, and other key human capabilities.